Prof. Maria Laura Belladonna,
Maria Laura Belladonna is an Associate Professor in cellular and experimental biology at the Pharmacology Section of the Department of Medicine and Surgery, University of Perugia, Italy. She is a biologist with a background in immunopharmacology. Graduated with honors in Drug Chemistry and Technology at the University of Perugia, in 1996 she obtained her PhD degree in Experimental Medicine, discussing a thesis on the immunogenicity acquired by drug- treated tumor antigens. After her PhD she was a research fellow under the supervision of Dr. JC Renauld at the Ludwig Institute for Cancer Research in Brussels, where she acquired great expertise in the production of recombinant heterodimeric cytokines and in the analysis of their signaling. Her areas of expertise are in vitro investigations of the molecular mechanisms underlying immunogenic and tolerogenic responses, with a specific focus on the effects of bioactive molecules released by biomaterials on oxidative stress, osteoclastogenesis, and inflammatory processes. Further research fields are tolerogenic cytokines, the tolerogenic enzyme indoleamine 2,3-dioxygenase 1 (IDO1), and tryptophan metabolism in murine experimental models of autoimmune diseases and in tumors; tumor biomarkers derived from tryptophan metabolism in human Non-Small Cell Lung Cancer (NSCLC); effects of plant-derived bioactive compounds in the regulation of inflammatory processes and osteoclastogenesis; and effects of oxidative stress molecules in bone-damaging diseases. She has contributed to several national and international projects and produced 91 peer-reviewed scientific full papers and 1 book chapter and has translated 7 book chapters. Full papers are included in the “NCBI USA” database and available at the Google Scholar URL https://scholar.google.it/citations?hl=it&user=TJ8gefYAAAAJ.